Title | Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results. |
Publication Type | Publication |
Year | 2018 |
Authors | González HM, Tarraf W, Vásquez P, Sanderlin AH, Rosenberg NI, Davis S, Rodriguez CJ, Gallo LC, Thyagarajan B, Daviglus M, Khambaty T, Cai J, Schneiderman N |
Journal | Diabetes Care |
Volume | 41 |
Issue | 7 |
Pagination | 1501-1509 |
Date Published | 2018 Jul |
ISSN | 1935-5548 |
Keywords | Adolescent, Adult, Aged, aging, Cognition, Cognition Disorders, Cross-Sectional Studies, ethnicity, executive function, Female, Hispanic or Latino, Humans, Male, Metabolic syndrome, Middle Aged, Young Adult |
Abstract | OBJECTIVE: Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in the U.S. and are also at increased risk for Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, and inflammation among diverse middle-aged and older Hispanics/Latinos.RESEARCH DESIGN AND METHODS: Cross-sectional data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analyzed to examine associations between neurocognition and MetS among diverse Hispanics/Latinos ( = 9,136; aged 45-74 years).RESULTS: MetS status was associated with lower global neurocognition, mental status, verbal learning and memory, verbal fluency, and executive function. Age significantly modified the associations between MetS and learning and memory measures. Significant associations between MetS and neurocognition were observed among middle-aged Hispanics/Latinos, and all associations remained robust to additional covariates adjustment.CONCLUSIONS: We found that MetS was associated with lower neurocognitive function, particularly in midlife. Our findings support and extend current hypotheses that midlife may be a particularly vulnerable developmental period for unhealthy neurocognitive aging. |
DOI | 10.2337/dc17-1896 |
Alternate Journal | Diabetes Care |
PubMed ID | 29716895 |
PubMed Central ID | PMC6014545 |
Grant List | P30 AG053760 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States R01 AG048642 / AG / NIA NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States RF1 AG054548 / AG / NIA NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States P30 DK111022 / DK / NIDDK NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States |
Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results.
MS#:
0625
ECI:
Manuscript Affiliation:
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
Manuscript Status:
Published