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Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

TitleGenome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2018
AuthorsDunn EC, Sofer T, Wang M-J, Soare TW, Gallo LC, Gogarten SM, Kerr KF, Chen C-Y, Stein MB, Ursano RJ, Guo X, Jia Y, Yao J, Rotter JI, Argos M, Cai J, Perreira K, Wassertheil-Smoller S, Smoller JW
Corporate AuthorsMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium
JournalJ Psychiatr Res
Volume99
Pagination167-176
Date Published2018 04
ISSN1879-1379
KeywordsAdolescent, Adult, Aged, Cohort Studies, Depression, Depressive Disorder, Female, genome-wide association study, Hispanic Americans, Humans, Male, Middle Aged, United States, Young Adult
Abstract

Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users. We estimated heritability due to common variants (h), and performed a GWAS of the three phenotypes. Replication was attempted in three independent Hispanic/Latino cohorts. We also performed sex-stratified analyses, analyzed a binary trait indicating probable depression, and conducted three trans-ethnic analyses. The three phenotypes exhibited significant heritability (h = 6.3-6.9%; p = .002) in the total sample. No SNPs were genome-wide significant in analyses of the three phenotypes or the binary indicator of probable depression. In sex-stratified analyses, seven genome-wide significant SNPs (one in females; six in males) were identified, though none were supported through replication. Four out of 24 loci identified in prior GWAS were nominally associated in HCHS/SOL. There was no evidence of overlap in genetic risk factors across ancestry groups, though this may have been due to low power. We conducted the largest GWAS of depression-related phenotypes in Hispanic/Latino adults. Results underscore the genetic complexity of depressive symptoms as a phenotype in this population and suggest the need for much larger samples.

DOI10.1016/j.jpsychires.2017.12.010
Alternate JournalJ Psychiatr Res
PubMed ID29505938
PubMed Central IDPMC6192675
Grant ListU01 MH087981 / MH / NIMH NIH HHS / United States
HHSN268201300005C / HL / NHLBI NIH HHS / United States
HHSN268201100001I / HL / NHLBI NIH HHS / United States
HHSN268201500003C / HL / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
N01HC95163 / HL / NHLBI NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
HHSN268201100004I / HL / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
HHSN268201100046C / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
HHSN268201100003C / WH / WHI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC95164 / HL / NHLBI NIH HHS / United States
N01HC95162 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
R35 HL135818 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
K01 MH102403 / MH / NIMH NIH HHS / United States
U01 MH109536 / MH / NIMH NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
HHSN271201100004C / AG / NIA NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
HHSN268201100002C / WH / WHI NIH HHS / United States
UL1 TR001420 / TR / NCATS NIH HHS / United States
N01HC95167 / HL / NHLBI NIH HHS / United States
U01 MH109532 / MH / NIMH NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
HHSN268201100002I / HL / NHLBI NIH HHS / United States
R01 MH113930 / MH / NIMH NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
U01 MH109528 / MH / NIMH NIH HHS / United States
HHSN268201100001C / WH / WHI NIH HHS / United States
HHSN268201100004C / WH / WHI NIH HHS / United States
MS#: 
0399
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
ECI: 
Manuscript Status: 
Published