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Association of Cardiac Structure and Function With Neurocognition in Hispanics/Latinos: The Echocardiographic Study of Latinos.

TitleAssociation of Cardiac Structure and Function With Neurocognition in Hispanics/Latinos: The Echocardiographic Study of Latinos.
Publication TypePublication
Year2018
AuthorsAlmahmoud MFaher, González HM, Swett K, Tarraf W, Schneiderman N, Kansal MM, Lamar M, Talavera GA, Rodriguez CJ
JournalMayo Clin Proc Innov Qual Outcomes
Volume2
Issue2
Pagination165-175
Date Published2018 Jun
ISSN2542-4548
Abstract

Objective: To study the associations of comprehensive measures of cardiac structure and function with multidimensional neurocognitive measures.Patients and Methods: The Echocardiographic Study of Latinos is a population-based cohort of Hispanic/Latino adults older than 45 years enrolled from October 1, 2011, through June 30, 2014. Neurocognitive measures included Word Fluency (WF), Brief-Spanish English Verbal Learning Test (B-SEVLT), and Digit Symbol Substitution Test. The B-SEVLT included B-SEVLT-recall and B-SEVLT-sum. Echocardiographic measures included cardiac structure, systolic and diastolic function, and myocardial strain. Multivariable regression models were fit using survey statistics and sampling probabilities.Results: A total of 1794 participants (mean age, 56±0.5 years; 56% women) were included in the analysis. In the adjusted model, higher left ventricular mass index was associated with lower B-SEVLT-sum and Digit Symbol Substitution Test scores. Left ventricular systolic dysfunction was associated with lower WF scores. Abnormal left ventricular geometry was associated with lower B-SEVLT-sum scores. Higher relative wall thickness was associated with B-SEVLT-recall and B-SEVLT-sum scores. Mitral annular relaxation velocities were associated with lower B-SEVLT-recall, B-SEVLT-sum, and WF scores. Higher mitral inflow to annular early diastolic velocity ratio was associated with lower B-SEVLT-recall and B-SEVLT-sum scores. Diastolic dysfunction was associated with lower B-SEVLT-sum scores. Finally, lower global longitudinal strain was associated with lower WF scores.Conclusion: Alterations in cardiac structure, systolic and diastolic function, and myocardial strain were associated with worse neurocognitive function. Further study is needed to determine the mechanisms (ie, impairment of cerebral flow and silent brain infarctions) mediating these heart-brain associations.

DOI10.1016/j.mayocpiqo.2018.02.003
Alternate JournalMayo Clin Proc Innov Qual Outcomes
PubMed ID30225446
PubMed Central IDPMC6124325
Grant ListR01 HL104199 / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
MS#: 
0403
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Central ECG Reading Center - Wake Forest University
ECI: 
Manuscript Affiliation: 
HCHS/SOL Baseline Visit - Central ECG Reading Center - Wake Forest University
Manuscript Status: 
Published