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Cerebral Hemodynamics in Sleep Apnea and Actigraphy-Determined Sleep Duration in a Sample of the Hispanic Community Health Study/ Study of Latinos.

TitleCerebral Hemodynamics in Sleep Apnea and Actigraphy-Determined Sleep Duration in a Sample of the Hispanic Community Health Study/ Study of Latinos.
Publication TypePublication
Year2019
AuthorsYang D, Rundek T, Patel SR, Cabral D, Redline S, Testai FD, Cai J, Wallace DM, Zee PC, Ramos AR
JournalJ Clin Sleep Med
Volume15
Issue1
Pagination15-21
Date Published2019 01 15
ISSN1550-9397
Keywordsactigraphy, Adult, Basilar Artery, Blood Flow Velocity, Cerebrovascular Circulation, Female, Hispanic Americans, Humans, Male, Middle Aged, Middle Cerebral Artery, sleep, Sleep Apnea, Obstructive, Time Factors, Ultrasonography, Doppler, Transcranial, Young Adult
Abstract

STUDY OBJECTIVES: We sought to evaluate cerebral hemodynamics in obstructive sleep apnea (OSA) and actigraphy-defined short sleep duration using transcranial Doppler ultrasound (TCD) blood flow velocity in a subsample of Hispanics/Latinos without stroke and cardiovascular disease.METHODS: The sample consisted of consecutive participants at the Miami site of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with overnight home sleep testing and 7 days of wrist actigraphy in the Sueño sleep ancillary study. Ninety-five participants had sleep data and TCD determined cerebral hemodynamics. We evaluated the association between OSA (apnea-hypopnea index [AHI] ≥ 5 events/h) and short sleep duration (< 6.8 hours; sample median) with cerebral blood flow velocities (CBFV) and pulsatility index (PI) for the middle cerebral (MCA) and basilar arteries (BA).RESULTS: Median age was 48 years (range 20-64) with 71% females. Twenty-eight percent of the sample had OSA (AHI ≥ 5 events/h) with median AHI of 10.0 (range 5.0-51.7) events/h. In unadjusted analyses, participants with OSA had lower median CBFV in the BA (30.5 cm/s [interquartile range:10.2] versus 39.4 cm/s [13.3] < .05), but not the MCA, whereas short sleepers had higher median vascular resistance in the MCA (PI = 0.92 [0.18] versus 0.86 [0.14] < .05) and BA (PI = 1.0 [0.17] versus 0.93 [0.24] < .05). After full adjustment, OSA was associated with decreased CBFV (β [SE] = -5.1 [2.5] < .05) in the BA. Short sleep was associated with increased PI (β [SE] = 0.05 [0.02] < .05) in the MCA.CONCLUSIONS: In this sample of Hispanic/Latinos, OSA was associated with decreased daytime blood flow velocity in the BA, whereas actigraphy-defined short sleep duration was associated with increased cerebrovascular pulsatility in the MCA.

DOI10.5664/jcsm.7560
Alternate JournalJ Clin Sleep Med
PubMed ID30621830
PubMed Central IDPMC6329545
Grant ListK24 HL127307 / HL / NHLBI NIH HHS / United States
KL2 TR000461 / TR / NCATS NIH HHS / United States
L60 MD005231 / MD / NIMHD NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
R01 HL098297 / HL / NHLBI NIH HHS / United States
MS#: 
0574
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Status: 
Published