| Title | Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). |
| Publication Type | Publication |
| Year | 2018 |
| Authors | González HM, Tarraf W, Jian X, Vásquez PM, Kaplan R, Thyagarajan B, Daviglus M, Lamar M, Gallo LC, Zeng D, Fornage M |
| Journal | Sci Rep |
| Volume | 8 |
| Issue | 1 |
| Pagination | 17578 |
| Date Published | 2018 Dec 13 |
| ISSN | 2045-2322 |
| Keywords | Adult, Aged, Alzheimer Disease, Apolipoproteins E, Cardiovascular Diseases, Cholesterol, Female, Genetic Variation, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Risk Factors, United States |
| Abstract | The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos. |
| DOI | 10.1038/s41598-018-35573-3 |
| Alternate Journal | Sci Rep |
| PubMed ID | 30546063 |
| PubMed Central ID | PMC6292877 |
MS#:
0657
ECI:
Manuscript Affiliation:
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
Manuscript Status:
Published