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Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL).

TitleApolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL).
Publication TypePublication
Year2018
AuthorsGonzález HM, Tarraf W, Jian X, Vásquez PM, Kaplan R, Thyagarajan B, Daviglus M, Lamar M, Gallo LC, Zeng D, Fornage M
JournalSci Rep
Volume8
Issue1
Pagination17578
Date Published2018 12 13
ISSN2045-2322
KeywordsAdult, Aged, Alzheimer Disease, Apolipoproteins E, Cardiovascular Diseases, Cholesterol, Female, Genetic Variation, Genotype, Hispanic Americans, Humans, Male, Middle Aged, Risk Factors, United States
Abstract

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.

DOI10.1038/s41598-018-35573-3
Alternate JournalSci Rep
PubMed ID30546063
PubMed Central IDPMC6292877
MS#: 
0657
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
ECI: 
Manuscript Affiliation: 
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
Manuscript Status: 
Published