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Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

TitleGenetic loci associated with heart rate variability and their effects on cardiac disease risk.
Publication TypePublication
Year2017
AuthorsNolte IM, M Munoz L, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B et al.
JournalNat Commun
Volume8
Pagination15805
Date Published2017 06 14
ISSN2041-1723
Keywordsblood pressure, Cohort Studies, European Continental Ancestry Group, Genetic Predisposition to Disease, genome-wide association study, Heart Diseases, heart rate, Humans, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Muscle Proteins, Polymorphism, Single Nucleotide, Potassium Channels, Quantitative Trait Loci, RGS Proteins, Risk Factors
Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74

DOI10.1038/ncomms15805
Alternate JournalNat Commun
PubMed ID28613276
PubMed Central IDPMC5474732
Grant ListR01 HL120393 / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
P01 GM099568 / GM / NIGMS NIH HHS / United States
MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
K23 HL114724 / HL / NHLBI NIH HHS / United States
R01 HL116747 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
I01 BX002558 / BX / BLRD VA / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
MS#: 
0289
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Genetic Analysis Center - University of Washington, Seattle
ECI: 
Manuscript Affiliation: 
HCHS/SOL Genetic Analysis Center - University of Washington, Seattle
Manuscript Status: 
Published