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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

TitleGenome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.
Publication TypePublication
Year2019
AuthorsShungin D, Haworth S, Divaris K, Agler CS, Kamatani Y, Lee MKeun, Grinde K, Hindy G, Alaraudanjoki V, Pesonen P, Teumer A, Holtfreter B, Sakaue S, Hirata J, Yu Y-H, Ridker PM, Giulianini F, Chasman DI, Magnusson PKE, Sudo T, Okada Y, Völker U, Kocher T, Anttonen V, Laitala M-L, Orho-Melander M, Sofer T, Shaffer JR, Vieira A, Marazita ML, Kubo M, Furuichi Y, North KE, Offenbacher S, Ingelsson E, Franks PW, Timpson NJ, Johansson I
JournalNat Commun
Volume10
Issue1
Pagination2773
Date Published2019 06 24
ISSN2041-1723
KeywordsDental Caries, Genetic Predisposition to Disease, genome-wide association study, Genomics, Heredity, Humans, Mendelian Randomization Analysis, Periodontitis, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Self Report
Abstract

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

DOI10.1038/s41467-019-10630-1
Alternate JournalNat Commun
PubMed ID31235808
PubMed Central IDPMC6591304
Grant ListDnr 2011-3372 / / Vetenskapsrådet (Swedish Research Council) / International
K23 DE026804 / DE / NIDCR NIH HHS / United States
R01 DE014899 / DE / NIDCR NIH HHS / United States
P30 DK116074 / DK / NIDDK NIH HHS / United States
C18281/A19169 / / Cancer Research UK (CRUK) / International
2015-02597 / / Vetenskapsrådet (Swedish Research Council) / International
MC_PC_15018 / MRC_ / Medical Research Council / United Kingdom
U01 DE018903 / DE / NIDCR NIH HHS / United States
U01 DE025046 / DE / NIDCR NIH HHS / United States
G9815508 / MRC_ / Medical Research Council / United Kingdom
4.1-2016-00416 / / Vetenskapsrådet (Swedish Research Council) / International
MS#: 
0490
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Genetic Analysis Center - University of Washington, Seattle
ECI: 
Yes
Manuscript Status: 
Published