Title | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. |
Publication Type | Publication |
Year | 2019 |
Authors | Shungin D, Haworth S, Divaris K, Agler CS, Kamatani Y, Lee MKeun, Grinde K, Hindy G, Alaraudanjoki V, Pesonen P, Teumer A, Holtfreter B, Sakaue S, Hirata J, Yu Y-H, Ridker PM, Giulianini F, Chasman DI, Magnusson PKE, Sudo T, Okada Y, Völker U, Kocher T, Anttonen V, Laitala M-L, Orho-Melander M, Sofer T, Shaffer JR, Vieira A, Marazita ML, Kubo M, Furuichi Y, North KE, Offenbacher S, Ingelsson E, Franks PW, Timpson NJ, Johansson I |
Journal | Nat Commun |
Volume | 10 |
Issue | 1 |
Pagination | 2773 |
Date Published | 2019 Jun 24 |
ISSN | 2041-1723 |
Keywords | Dental Caries, Genetic Predisposition to Disease, genome-wide association study, Genomics, Heredity, Humans, Mendelian Randomization Analysis, Periodontitis, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Self Report |
Abstract | Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. |
DOI | 10.1038/s41467-019-10630-1 |
Alternate Journal | Nat Commun |
PubMed ID | 31235808 |
PubMed Central ID | PMC6591304 |
Grant List | Dnr 2011-3372 / / Vetenskapsrådet (Swedish Research Council) / International K23 DE026804 / DE / NIDCR NIH HHS / United States R01 DE014899 / DE / NIDCR NIH HHS / United States P30 DK116074 / DK / NIDDK NIH HHS / United States C18281/A19169 / / Cancer Research UK (CRUK) / International 2015-02597 / / Vetenskapsrådet (Swedish Research Council) / International MC_PC_15018 / MRC_ / Medical Research Council / United Kingdom U01 DE018903 / DE / NIDCR NIH HHS / United States U01 DE025046 / DE / NIDCR NIH HHS / United States G9815508 / MRC_ / Medical Research Council / United Kingdom 4.1-2016-00416 / / Vetenskapsrådet (Swedish Research Council) / International |
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.
MS#:
0490
ECI:
Yes
Manuscript Status:
Published