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A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).

TitleA research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).
Publication TypePublication
Year2019
AuthorsGonzález HM, Tarraf W, Fornage M, González KA, Chai A, Youngblood M, Abreu Mde Los Ang, Zeng D, Thomas S, Talavera GA, Gallo LC, Kaplan R, Daviglus ML, Schneiderman N
JournalAlzheimers Dement
Volume15
Issue12
Pagination1624-1632
Date Published2019 12
ISSN1552-5279
KeywordsAlzheimer Disease, Cognitive Aging, Cognitive Dysfunction, Health Services Research, Hispanic Americans, Humans, Middle Aged, Neuropsychological Tests, Public Health, United States
Abstract

Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay ahead in coming decades. The primary purpose of this Perspectives article was to provide a new research framework for advancing Latino ADRD knowledge, encompassing the unique sociocultural, cardiometabolic, and genomic aspects of Latino health, aging, and ADRD. In addition, we describe some of the research challenges to progress in Latino ADRD research. Finally, we present the Study of Latinos - Investigation of Neurocognitive Aging (SOL-INCA) as an example of implementing this new framework for advancing Latino ADRD research.

DOI10.1016/j.jalz.2019.08.192
Alternate JournalAlzheimers Dement
PubMed ID31759880
PubMed Central IDPMC6925624
Grant ListUH3 NS100605 / NS / NINDS NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
U01 AG052409 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
U01 AG049505 / AG / NIA NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
R01 AG054076 / AG / NIA NIH HHS / United States
P50 AG005131 / AG / NIA NIH HHS / United States
R01 AG048642 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
0590
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
ECI: 
Manuscript Affiliation: 
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
Manuscript Status: 
Published