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Adiposity, Depression Symptoms and Inflammation in Hispanic/Latino Youth: Results From HCHS/SOL Youth.

TitleAdiposity, Depression Symptoms and Inflammation in Hispanic/Latino Youth: Results From HCHS/SOL Youth.
Publication TypePublication
Year2020
AuthorsNguyen-Rodriguez ST, Gallo LC, Isasi CR, Buxton OM, Thomas KMS, Sotres-Alvarez D, Redline S, Castañeda SF, Carnethon MR, Daviglus ML, Perreira KM
JournalAnn Behav Med
Volume54
Issue7
Pagination529-534
Date Published2020 06 12
ISSN1532-4796
Keywordsadiposity, Adolescent, Biomarkers, C-Reactive Protein, Child, Cohort Studies, Cross-Sectional Studies, Depression, Female, Hispanic Americans, Humans, Inflammation, Male, Plasminogen Activator Inhibitor 1, Risk Factors, sleep, United States
Abstract

BACKGROUND: Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk.PURPOSE: To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference).METHODS: Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics.RESULTS: Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (β = .011, p = .047) but not PAI-1 (p = .285). Percentage body fat and waist circumference were positively related to depression symptoms (p = .026 and p = .028, respectively) and log hs-CRP (p < .001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI: .0006, .0119) and waist circumference (95% CI: .0004, .0109) were statistically significant.CONCLUSIONS: Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years.

DOI10.1093/abm/kaz070
Alternate JournalAnn Behav Med
PubMed ID32043152
PubMed Central IDPMC7291328
Grant ListK01 HL140283 / HL / NHLBI NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
UL1 TR002550 / TR / NCATS NIH HHS / United States
MS#: 
0558
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Manuscript Affiliation: 
Field Center: San Diego (San Diego State University)
Manuscript Status: 
Published