Title | Adiposity, Depression Symptoms and Inflammation in Hispanic/Latino Youth: Results From HCHS/SOL Youth. |
Publication Type | Publication |
Year | 2020 |
Authors | Nguyen-Rodriguez ST, Gallo LC, Isasi CR, Buxton OM, Thomas KMS, Sotres-Alvarez D, Redline S, Castañeda SF, Carnethon MR, Daviglus ML, Perreira KM |
Journal | Ann Behav Med |
Volume | 54 |
Issue | 7 |
Pagination | 529-534 |
Date Published | 2020 Jun 12 |
ISSN | 1532-4796 |
Keywords | adiposity, Adolescent, Biomarkers, C-Reactive Protein, Child, Cohort Studies, Cross-Sectional Studies, Depression, Female, Hispanic or Latino, Humans, Inflammation, Male, Plasminogen Activator Inhibitor 1, Risk Factors, sleep, United States |
Abstract | BACKGROUND: Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk.PURPOSE: To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference).METHODS: Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics.RESULTS: Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (β = .011, p = .047) but not PAI-1 (p = .285). Percentage body fat and waist circumference were positively related to depression symptoms (p = .026 and p = .028, respectively) and log hs-CRP (p < .001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI: .0006, .0119) and waist circumference (95% CI: .0004, .0109) were statistically significant.CONCLUSIONS: Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years. |
DOI | 10.1093/abm/kaz070 |
Alternate Journal | Ann Behav Med |
PubMed ID | 32043152 |
PubMed Central ID | PMC7291328 |
Grant List | K01 HL140283 / HL / NHLBI NIH HHS / United States P2C HD050924 / HD / NICHD NIH HHS / United States P30 DK111022 / DK / NIDDK NIH HHS / United States UL1 TR002550 / TR / NCATS NIH HHS / United States |
Adiposity, Depression Symptoms and Inflammation in Hispanic/Latino Youth: Results From HCHS/SOL Youth.
MS#:
0558
ECI:
Manuscript Affiliation:
Field Center: San Diego (San Diego State University)
Manuscript Status:
Published