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Current Smoking Raises Risk of Incident Hypertension: Hispanic Community Health Study-Study of Latinos.

TitleCurrent Smoking Raises Risk of Incident Hypertension: Hispanic Community Health Study-Study of Latinos.
Publication TypePublication
AuthorsKaplan RC, Baldoni PL, Strizich GM, Pérez-Stable EJ, Saccone NL, Peralta CA, Perreira KM, Gellman MD, Williams-Nguyen JS, Rodriguez CJ, Lee DJ, Daviglus M, Talavera GA, Lash JP, Cai J, Franceschini N
JournalAm J Hypertens
Date Published2021 Mar 11
KeywordsAdolescent, Adult, Aged, Follow-Up Studies, Hispanic or Latino, Humans, Hypertension, Incidence, Middle Aged, Risk Factors, Smoking, Young Adult

BACKGROUND: Hypertension has been implicated as a smoking-related risk factor for cardiovascular disease but the dose-response relationship is incompletely described. Hispanics, who often have relatively light smoking exposures, have been understudied in this regard.METHODS: We used data from a 6-year follow-up study of US Hispanic adults aged 18-76 to address the dose-response linking cigarette use with incident hypertension, which was defined by measured blood pressure above 140/90 mm Hg or initiation of antihypertensive medications. Adjustment was performed for potential confounders and mediators, including urinary albumin-to-creatinine ratio which worsened over time among smokers.RESULTS: Current smoking was associated with incident hypertension, with a threshold effect above 5 cumulative pack-years of smoking (vs. never smokers, hazard ratio for hypertension [95% confidence interval] of 0.95 [0.67, 1.35] for 0-5 pack-years, 1.47 [1.05, 2.06] for 5-10 pack-years, 1.40 [1.00, 1.96] for 10-20 pack-years, and 1.34 [1.09, 1.66] for ≥20 pack-years, P = 0.037). In contrast to current smokers, former smokers did not appear to have increased risk of hypertension, even at the highest cumulative pack-years of past exposure.CONCLUSIONS: The results confirm that smoking constitutes a hypertension risk factor in Hispanic adults. A relatively modest cumulative dose of smoking, above 5 pack-years of exposure, raises risk of hypertension by over 30%. The increased hypertension risk was confined to current smokers, and did not increase further with higher pack-year levels. The lack of a smoking-hypertension association in former smokers underscores the value of smoking cessation.

Alternate JournalAm J Hypertens
PubMed ID32968788
PubMed Central IDPMC7951044
Grant ListP30 ES010126 / ES / NIEHS NIH HHS / United States
R21 HL140385 / HL / NHLBI NIH HHS / United States
R01 DK117445 / DK / NIDDK NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
R01 MD012765 / MD / NIMHD NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: